Mannose hyperbranched dendritic polymers interact with clustered organization of DC-SIGN and inhibit gp120 binding

Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding.

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Dendritic nanocarriers based on hyperbranched polymers.

Hyperbranched polymers are obtained through one-step polymerization reactions and exhibit properties that are very similar to those of perfect dendrimer analogues. Therefore, hyperbranched polymers are a suitable alternative for perfect dendrimers as building blocks for dendritic nanocarrier systems. With regard to using soluble hyperbranched polymers as carrier systems, their flexible chains a...

Binding of HIV-1 gp120 to DC-SIGN Promotes ASK-1-Dependent Activation-Induced Apoptosis of Human Dendritic Cells

During disease progression to AIDS, HIV-1 infected individuals become increasingly immunosuppressed and susceptible to opportunistic infections. It has also been demonstrated that multiple subsets of dendritic cells (DC), including DC-SIGN⁺ cells, become significantly depleted in the blood and lymphoid tissues of AIDS patients, which may contribute to the failure in initiating effective host im...

Glycodendritic structures: tools to interact with DC-SIGN

Javier Rojo received a BSc in Organic Chemistry in 1989, MSc degree in 1990 at the Autónoma University (UAM), Madrid (Spain). Then, he was embarked in the doctoral program to obtain a PhD degree under the supervision of Prof. Juan Carlos Carretero at UAM in 1995. He was a postdoctoral fellow with Prof. Jean-Marie Lehn at the University Louis Pasteur in Strasbourg (France) (19951998) and with Pr...

Targeting of DC-SIGN on Human Dendritic